Best sexologist. Male Infertility Male infertility refers to a male's inability to cause pregnancy in a fertile female. In humans it accounts for 40-50% of infertility. It affects approximately 20% of all men.Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity.Best sexologist. Defect in the sperm production process in the male's testes is the major cause of male infertility and this problem is reported in about two thirds of infertile men. The consequences of infertility are manifold and in many cultures, inability to conceive bears a stigma.Best sexologist. Infertility can have a big emotional impact on you and your partner and continuous mental stress brings sexual dysfunction in men.Best sexologist. Depression, anxiety, and marriage problems may occur. Best sexologist.